The unique nature of landscapes has challenged our ability to make generalizations about the effects of bottom-up controls on fire regimes. For four geographically distinct fire-prone landscapes in western North America, we used a consistent simulation approach to quantify the influence of three key bottom-up factors, ignitions, fuels, and topography, on spatial patterns of fire likelihood. We first developed working hypotheses predicting the influence of each factor based on its spatial structure (i.e., autocorrelation) in each of the four study areas. We then used a simulation model parameterized with extensive fire environment data to create high-resolution maps of fire likelihood, or burn probability (BP). To infer the influence of each bottom-up factor within and among study areas, these BP maps were compared to parallel sets of maps in which one of the three bottom-up factors was randomized. Results showed that ignition pattern had a relatively minor influence on the BP across all four study areas, whereas the influence of fuels was large. The influence of topography was the most equivocal among study areas; it had an insignificant influence in one study area and was the dominant control in another. We also found that the relationship between the influence of these factors and their spatial structure appeared nonlinear, which may have important implications for management activities aimed at attenuating the effect of fuels or ignitions on wildfire risk. This comparative study using landscapes with different biophysical and fire regime characteristics demonstrates the importance of employing consistent methodology to pinpoint the influence of bottom-up controls.