By the turn of the century, and under the current rate of climate change, many landscapes in the U.S. may have climates incompatible with current vegetation. One adaptation strategy at the nexus of native plant transfer guidelines and climate change is assisted migration, also known as managed relocation, defined as the intentional movement of plants in response to climate change. Although researchers propose frameworks and guidelines on how to apply assisted migration of native plants, no consensus exists on implementation in the U.S. because of ecological and economic concerns and lack of supporting data. To identify knowledge gaps and provide a central foundation for collaboration, researchers compiled a literary database about native plant transfer guidelines, climate change, and assisted migration. The database connects all pieces of information from peer-review journal articles to decision-support tools. As a result, scientists, land managers, and university students are informed about climate change and assisted migration through presentations and publications, and a holistic-approach workshop that covers the historical, biological, social, legal, and ethical aspects of assisted migration.