Worldwide, many wood-inhabiting fungi have not yet been described and classified. Many of these fungi have the ability to degrade or breakdown wood. Although essential for healthy forests, some decomposing fungal species may pose a serious threat of forest disease. The genus Epithele was known to consist of 17 species worldwide. As part of the scientific effort to identify new fungi, a Forest Service scientist found four new species: E. belizensis from Belize, E. ceracea from Belize and Venezuela, E. reunionis from Réunion, and E. ryvardenii from Venezuela. Conserving biodiversity is a global concern, as is the threat posed by invasive species. Evaluating positive beneficial and potential threats from these and related fungi begins with their identification and classification.