The International Institute of Tropical Forestry in Puerto Rico exemplifies the USDA Forest Service’s mission of working cross-jurisdictions, building science capacity, and interpretation of the contemporary issues relevant to society and resource conservation. In addition, it has a long track record of doing so in cooperation with partners and stakeholders, while acting as co-conveners and co-facilitators for collaborative learning and decision making. As the institute continues to collaboratively explore new frontiers in science, staff members recognize the potential of forestry, atmospheric sciences, modeling, hydrology, plant physiology, and microbial ecology as core to the understanding of tropical forests in the Anthropocene. The institute celebrated its 75th anniversary with the publication of a special issue of Forests titled Tropical Forest Ecology and Management for the Anthropocene. The Issue is based on presentations delivered in a symposium held in San Juan, Puerto Rico, in 2014. It augments a quarter century of scientific knowledge and capitalizes on a unique set of synergies chartered by a strategy based on shared stewardship, innovative transdisciplinary collaborations, and breakthroughs in science and technology. The manuscripts contained in the special issue present advancements in our approach to the development of policies for effective governance and stewardship, long-term focus for the understanding of ecosystem processes and functions, novelties given attention to cross-boundary collaborative approaches to science, and proposed alternative institutional visions in the Anthropocene.