The Science Framework for Conservation and Restoration of the Sagebrush Biome provides a strategic, multiscale approach for prioritizing areas for management and determining effective management strategies across the sagebrush biome that exists in 11 western States. The framework uses a geospatial process in which sagebrush ecosystem resilience to disturbance and resistance to nonnative, invasive plant species is linked to information on the habitat requirements of sagebrush obligate species. Forest Service scientists assess the predominant ecosystem and land use and development threats, and a habitat matrix is used to help decision makers evaluate risks and determine appropriate management strategies at regional and local scales. The framework provides a new and valuable approach that helps to ensure conservation and restoration actions are implemented where they will have the greatest benefits. Jeanne Chambers, a research ecologist at the Forest Service’s Rocky Mountain Research Station, led the team of scientists and managers who developed the framework. . The team included individuals from the U.S. Department of Agriculture Forest Service and Natural Resources and Conservation Service, U.S. Department of the Interior USGS, Bureau of Land Management, and Fish and Wildlife Service, the University of Wyoming, the Western Association of Fish and Wildlife Agencies, and individuals from the departments responsible for wildlife in the states of Idaho, Nevada, Montana, Wyoming and Colorado.