4090.13-93-1 Transmittal
                                      Page 1 of 3

                     FOREST SERVICE HANDBOOK
                           WASHINGTON

        FSH 4090.13 - GOOD LABORATORY PRACTICES HANDBOOK

                   Amendment No.  4090.13-93-1

                   Effective November 10, 1993


POSTING NOTICE.  Amendments are numbered consecutively by 
Handbook number and calendar year.  Post document in numerical 
order of chapters (1109.12, sec. 4.32, ex. 01).  Remove entire 
national text of the Handbook and replace with this amendment.  
DO NOT REMOVE SUPPLEMENTS OR INTERIM DIRECTIVES.  Retain this 
transmittal as the first page of this document.

    New Document Names                      New Pages

    4090.13, Contents                           2
    4090.13,0 Code Contents                     1
    4090.13,0 Code                             28
    4090.13,10 Contents                         1
    4090.13,10                                  3
    4090.13,20 Contents                         1
    4090.13,20                                  4
    4090.13,30 Contents                         1
    4090.13,30                                  2
    4090.13,40 Contents                         1
    4090.13,40                                  4
    4090.13,50 Contents                         1
    4090.13,50                                 25
    4090.13,60 Contents                         1
    4090.13,60                                 25
    4090.13,70 Contents                         1
    4090.13,70                                  8
    4090.13,80 Contents                         1
    4090.13,80                                  4
    4090.13,90 Contents                         1
    4090.13,90                                 16

Digest:

This Handbook provides direction on the principles and 
requirements of Good Laboratory Practice (GLPs) for Forest 
Service management and technical personnel.  Any study that is 
performed with the intention of submitting the data to the U.S. 
Environmental Protection Agency or the U.S. Food and Drug 
Administration in support of a research or marketing permit must 
follow GLP standards.

01 - 06.5 - Sets forth Authority (sec. 01), Policy (sec. 03), 
Responsibility (sec. 04), Definitions (sec. 05), and References 
(sec. 06) in the zero code chapter for the new Handbook on Good 
Laboratory Practices.

11 - 12.4 - Establishes a new chapter that provides direction on 
the applicability of Good Laboratory Practices (GLPs) (sec. 11) 
and aspects of compliance (sec. 12). 

20.3 - 22 - Establishes a new chapter that provides direction on 
staffing requirements and training for personnel conducting, or 
involved with, Good Laboratory Practices.

30.3 - 35 - Establishes a new chapter that provides policy and 
direction to determine requirements for test system care 
facilities (sec. 31); test system supply facilities (sec. 32); 
facilities for handling test, control, and reference substances 
(sec. 33); laboratory facilities (sec. 34); and archiving 
facilities (sec. 35) where Good Laboratory Practices are 
conducted or stored.

40.3 - 42.3 - Establishes a new chapter that provides direction 
on equipment requirements including equipment design (sec. 41) 
and calibration and maintenance (sec. 42) for studies complying 
with Good Laboratory Practices.

50.3 - 55.33 - Establishes a new chapter that provides direction 
on facility operations required for Good Laboratory Practices, 
including preparation of master schedule (sec. 51); standard 
operating procedures (sec. 52); reagents and solutions (sec. 53); 
test system care (sec. 54); and characterization, handling, and 
mixing with carriers of test, control, and reference substances 
(sec. 55).

61 - 62.32 - Establishes a new chapter that provides direction on 
the preparation of protocols and collection of raw data for Good 
Laboratory Practices.

70.4 - 73.3 - Establishes a new chapter, Records, Reports, and 
Archiving that provides direction on reporting study results 
(sec. 71), archiving (sec. 72).

80.1 - 81.2 - Establishes a new chapter that provides direction 
on the requirements and duties of local and national Quality 
Assurance Units in support of Good Laboratory Practices.

90.1 - 93.38 - Establishes a new chapter that provides direction 
on inspections conducted by local and national Quality Assurance 
Units (sec. 91 and 92) and the U.S. Environmental Protection 
Agency (sec. 93) in conjunction with Good Laboratory Practices.

This Handbook is now available electronically in the National 
Information Center in the same format as the paper copy.  
Henceforth, amendments to this Handbook will be issued to Forest 
Service units electronically on a document basis.




DAVID G. UNGER
Acting Chief