4090.13,50 Contents Page 1 of 1 FSH 4090.13 - GOOD LABORATORY PRACTICES HANDBOOK WO AMENDMENT 4090.13-93-1 EFFECTIVE 11/10/93 CHAPTER 50 - FACILITY OPERATION Contents 50.3 Policy 51 MASTER SCHEDULE 51.04 Responsibility 51.1 Contents 51.2 Updates 52 STANDARD OPERATING PROCEDURES FOR OVERALL OPERATIONS 52.1 Format 52.11 Examples of Standard Operating Procedures 52.2 Topics 52.3 Changes and Deviations 53 REAGENTS AND SOLUTIONS 54 TEST SYSTEM CARE 54.1 Standard Operating Procedures for Test System Care 54.2 Prevention and Treatment of Incidental Disease 54.3 Identification 54.4 Separation of Species 54.5 Detection of Contaminants 54.6 Pest Control 54.7 Acclimatization 55 TEST, CONTROL, AND REFERENCE SUBSTANCES 55.1 Characterization 55.11 General Considerations 55.12 Solubility and Stability 55.13 Storage Containers 55.14 Retention of Reserve Samples 55.2 Handling 55.21 Standard Operating Procedures 55.22 Chain of Custody 55.23 Documentation 55.3 Mixing with Carriers 55.31 Analyses 55.32 Labeling 55.33 Vehicles